Efficacy and Tolerability of Trandolapril in Mild- to-moderate Hypertension: A Double-blind Comparison with Enalapril

Hypertension is one of the most prevalent vascular diseases in the world and posses a major public health problem. Angiotensinconverting enzyme inhibitors (ACEIs) are accepted as first-line therapy in the treatment of hypertension and heart failure.1 The principle antihypertensive effect is through renin-angiotensin-aldosterone (RAA) mechanism.2 They offer distinct advantages such as preventing or reversing cardiovascular remodeling,3 diabetic complications,4 improving endothelial function5 and also enhancing fibrinolysis.6 The American Heart Association and American College of Cardiology (AHA/ACC) recommend ACEIs as standard therapy in patients who are at high-risk for cardiovascular morbidity and mortality.7 In recent years, there has been a rapid growth in the number of Efficacy and Tolerability of Trandolapril in Mildto-moderate Hypertension: A Double-blind Comparison with Enalapril